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目的:考察室温([25±1)℃]下,氟康唑氯化钠注射液与甲磺酸帕珠沙星注射液配伍的稳定性,为临床合理用药提供科学依据。方法:采用反相高效液相色谱法,色谱柱为Agilent HC C18,乙腈-0.05 mol.L-1磷酸二氢钾溶液(18︰82)为流动相,测定配伍液中氟康唑与甲磺酸帕珠沙星0～6 h内的含量变化,并观察配伍液的外观及pH值。结果:氟康唑氯化钠注射液与甲磺酸帕珠沙星注射液6 h内配伍液外观、pH及含量均无明显变化。结论:在室温([25±1)℃]下,氟康唑氯化钠注射液与甲磺酸帕珠沙星注射液配伍后6 h内可使用。
Objective: To investigate the stability of compatibility of fluconazole sodium chloride injection and pazufloxacin mesylate injection at room temperature ([25 ± 1] ℃], and to provide a scientific basis for clinical rational drug use. Methods: The mobile phase consisted of Agilent HC C18, acetonitrile-0.05 mol·L-1 potassium dihydrogen phosphate solution (18︰82) and reversed-phase high performance liquid chromatography (RP-HPLC) Acid Pazufloxacin content changes within 0 ~ 6 h, and observe the appearance of the compatibility of the solution and pH value. Results: The appearance, pH and content of compatibilized liquid of fluconazole sodium chloride injection and pazufloxacin mesylate injection within 6 h did not change significantly. Conclusion: Fluconazole sodium chloride injection can be used within 6 hours after compatibility with pazufloxacin mesylate injection at room temperature ([25 ± 1) ℃].