目的：研究西洋参二醇组皂甙对心肌缺血与再灌注损伤的临床保护效果。方法：将３０例心脏直视手术病人随机分成两组（每组１５例病人），对照组采用Ｓｔ．ＴｈｏｍａｓⅡ号液，观察组在Ｓｔ．ＴｈｏｍａｓⅡ号液基础上加入西洋参二醇组皂甙（８０ｍｇ／Ｌ），分别于升主动脉阻断前、阻断１５ｍｉｎ，开放循环５ｍｉｎ、２０ｍｉｎ及术后１２ｈ、２４ｈ采血，检血清内ＳＯＤ、ＧＳＨ－Ｐｘ、ＬＰＯ值。结果：观察组与对照组相比ＳＯＤ、ＧＳＨ－Ｐｘ值明显高于对照组（Ｐ＜００５，Ｐ＜００１），ＬＰＯ值明显低于对照组（Ｐ＜００５，Ｐ＜００１）。结论：西洋参二醇组皂甙对心肌缺血与再灌注损伤有明确的保护效果 Objective: To study the clinical protective effect of the American ginseng saponins on myocardial ischemia and reperfusion injury. Methods: Thirty patients undergoing open heart surgery were randomly divided into two groups (15 patients in each group). The control group was treated with St. Thomas II fluid, observation group in St. On the Thomas II liquid basis, the American ginsenoside saponin (80 mg/L) was added. Blood was taken before the ascending aorta was occluded, blocked for 15 min, opened for 5 min, 20 min, and 12 h and 24 h after the operation. Serum SOD, GSH- were measured. Px, LPO value. Results: Compared with the control group, the SOD and GSH-Px values ​​in the observation group were significantly higher than those in the control group (P<005, P<001), and the LPO value was significantly lower in the observation group than in the control group (P<005, P< 001). Conclusion: American ginsenoside saponins have a definite protective effect on myocardial ischemia and reperfusion injury