虽然抗胆碱酯酶剂可使乙酰胆碱暂时增加,临床症状获一过性改善,但这仅是一种对症疗法,而且许多小儿重症肌无力对抗胆碱酯酶剂常可产生一定的抗药性,而达不到满意的效果。现今认为重症肌无力系自体免疫性疾病,从免疫抑制的角度出发,我们在1978年—1980年间对13例患儿采用了环磷酰胺疗法,现将治疗结果报告如下。 Although anticholinesterase agents temporarily increase acetylcholine and improve transient clinical symptoms, this is only a symptomatic treatment and many pediatric myasthenia gravis may often produce some resistance to cholinesterase agents, But not satisfied with the results. Now that myasthenia gravis is an autoimmune disease, from the immunosuppressive point of view, we used cyclophosphamide in 13 patients between 1978 and 1980 and the results are reported below.