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在对体外新生大白鼠（0～1d）大脑皮层神经细胞进行原代培养的基础上，分别加入不同浓度卡马西平（Carbamazepine，CBZ），继续培养3d。检测乳酸脱氨酶（LDH）释出率双膜流动性。结果显示：高浓度的CBZ（24mg／L）可导致神经细胞LDH释出率明显升高（P<0．01）、膜流动性明显降低（P＜0．01）。提示高浓度卡马西平对神经细胞存在有毒性作用。
On the basis of primary cultured cerebral cortex neurons of neonatal rats (0 ~ 1d) in vitro, different concentrations of carbobarbazine (CBZ) were added separately and cultured for 3 days. Detection of lactate deaminase (LDH) release rate of dual membrane fluidity. The results showed that high concentrations of CBZ (24 mg / L) resulted in a significant increase of LDH release rate (P <0.01) and a significant decrease of membrane fluidity (P <0.01). Tip high concentrations of carbamazepine on the existence of toxic effects of nerve cells.