论文部分内容阅读
目的观察纳洛酮治疗AECOPD并发Ⅱ型呼吸衰竭的临床疗效。方法将65例病例随机分为治疗组及对照组,两组均予以积极控制感染,持续低流量吸氧,解痉平喘,止咳化痰,营养支持等综合治疗。治疗组在此基础上加用纳洛酮注射剂,首剂负荷量0.8mg加入生理盐水20ml中静脉推注,以后给予纳洛酮注射剂2mg加入生理盐水100ml中,缓慢持续静脉滴入,12h/次,24h纳洛酮总剂量为4mg,连用3d。结果治疗组总有效率显著高于对照组(P<0.05);动脉血气分析指标:动脉血氧分压(PaO2)显著高于对照组(P<0.05)、动脉血二氧化碳分压(PaCO2)显著低于对照组(P<0.05);结论纳洛酮治疗AECOPD合并呼吸衰竭临床疗效确切。
Objective To observe the clinical efficacy of naloxone in the treatment of AECOPD complicated with respiratory failure. Methods Sixty-five cases were randomly divided into treatment group and control group. Both groups were given positive control of infection, sustained low-flow oxygen, antispasmodic and anti-asthma, cough and phlegm, nutritional support and other comprehensive treatment. On the basis of this, the treatment group added naloxone injection, and the first dose of 0.8 mg was injected into the middle of 20 ml of normal saline. After that, 2 mg of naloxone injection was added to 100 ml of normal saline and slowly instilled intravenously for 12 hours , Naloxone total dose of 4mg 24h, once every 3d. Results The total effective rate of the treatment group was significantly higher than that of the control group (P <0.05). Arterial blood gas analysis showed that PaO2 was significantly higher (P <0.05) and PaCO2 Lower than the control group (P <0.05); Conclusion Naloxone treatment of AECOPD with respiratory failure clinical curative effect.