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目的了解住院患者真菌感染的种类及其耐药特点,为使用抗真菌药物提供病原学依据。方法收集医院2008年1-12月住院患者送检标本,分别进行真菌培养及药物敏感试验。结果共检出589株假丝酵母菌属,其中白色假丝酵母菌最多,有411株,占69.78%,其次,热带假丝酵母菌89株,占14.60%;假丝酵母菌属对氟康唑、伊曲康唑的耐药率较高,分别为39.39%和61.46%,而两性霉素B、5-氟胞嘧啶的耐药率较低,分别为3.57%和9.34%。结论白色假丝酵母菌是真菌感染的主要病原菌,合理选用抗真菌药物是防治真菌感染的关键。
Objective To understand the types of fungal infections in hospitalized patients and their drug resistance characteristics and to provide etiological evidence for the use of antifungal agents. Methods The specimens of hospitalized patients from January to December in 2008 were collected for fungal culture and drug susceptibility tests. Results A total of 589 Candida species were detected, of which Candida albicans was the most, with 411 strains accounting for 69.78%, followed by Candida tropicalis 89 strains accounting for 14.60%. Candida species were susceptible to Fluconazole The resistance rates of azole and itraconazole were high, which were 39.39% and 61.46% respectively, while those of amphotericin B and 5-fluorocytosine were lower, which were 3.57% and 9.34% respectively. Conclusion Candida albicans is the main pathogen of fungal infection. The rational selection of antifungal agents is the key to control fungal infection.