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目的:探讨睾丸生殖细胞肿瘤的诊断、治疗、预后情况及对性功能的影响。方法:对1 992年3月～2006年4月收住院的睾丸生殖细胞肿瘤患者的临床及随访资料进行回顾性分析和总结。结果:精原细胞瘤(SGCT)患者平均发病年龄40.3岁,比非精原细胞瘤(NSGCT)大6.9岁;B超显示,SGCT多表现为低回声,NSGCT多为不均匀回声;两者5年总生存率分别为93.94%、82.35%;疾病或治疗相关性性功能障碍发生率14.29%。结论:①血清肿瘤标志物、超声、腹部CT检查对于睾丸生殖细胞肿瘤的诊断、临床分期及顶后判断有一定参考价值。②SGCTⅠ期患者单纯手术与手术加放疗疗效相当,Ⅱ期患者应给予手术加放疗;NSGCT患者应给予手术加化疗等综合治疗。③睾丸肿瘤及相关治疗对性功能影响较小,勃起功能障碍主要与放疗有关。
Objective: To explore the diagnosis, treatment, prognosis of testicular germ cell tumor and its effect on sexual function. Methods: The clinical and follow-up data of patients with testicular germ cell tumors admitted from March 1992 to April 2006 were retrospectively analyzed and summarized. Results: The average age of onset of seminoma (SGCT) was 40.3 years, which was 6.9 years longer than that of non-seminoma (NSGCT). Ultrasonography showed low echogenicity in SGCT and non-uniform echogenicity in NSCT. The overall survival rates were 93.94% and 82.35%, respectively. The incidence of disease or treatment-related dysfunction was 14.29%. Conclusion: ① Serum tumor markers, ultrasound, abdominal CT examination for the diagnosis of testicular germ cell tumors, clinical stage and post-judgment to a certain reference value. ② SGCT Ⅰ surgery alone surgery and surgery plus radiotherapy effect equivalent, Ⅱ patients should be given surgery plus radiotherapy; NSGCT patients should be given surgery and chemotherapy and other comprehensive treatment. ③ Testicular tumor and related treatment of sexual function less affected, erectile dysfunction mainly associated with radiotherapy.