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目的探讨N-cadherin和相关因子β-catenin mRNA在人脑干和幕上胶质瘤中的表达。方法采用RT-PCR法检测N-cadherin和β-catenin mRNA在18例脑干胶质瘤和18例幕上胶质瘤中的表达。结果 N-cadherin mRNA在脑干和幕上胶质瘤中的表达无显著性差异(P>0.05),β-catenin mRNA在脑干胶质瘤中的表达高于幕上胶质瘤(t=2.255,P<0.05);N-cadherin mRNA在脑干胶质瘤中随着肿瘤级别的升高而增高(t=2.711,P<0.05),在幕上胶质瘤各级别表达无显著性差异。β-catenin mRNA在不同级别脑干和幕上胶质瘤中的表达均无显著性差异(P>0.05);N-cadherin和β-catenin mRNA在脑干和幕上胶质瘤中的表达均呈正相关(r=0.480,r=0.809,均P<0.05)。结论 N-cadherin和β-catenin的过度表达在人脑干胶质瘤的侵袭及恶性进展中起着重要作用。
Objective To investigate the expression of N-cadherin and related factor β-catenin mRNA in human brain stem and supratentorial glioma. Methods The expression of N-cadherin and β-catenin mRNA in 18 cases of gliomas and 18 cases of supratentorial gliomas were detected by RT-PCR. Results There was no significant difference in the expression of N-cadherin mRNA between brainstem and supratentorial glioma (P> 0.05). The expression of β-catenin mRNA in glioma was higher than that of supratentorial glioma (t = 2.255, P <0.05). The expression of N-cadherin mRNA in brain stem gliomas increased with tumor grade (t = 2.711, P <0.05), but there was no significant difference in the expression of glioma . The expression of β-catenin mRNA in brain stem and supratentorial glioma had no significant difference (P> 0.05). The expressions of N-cadherin and β-catenin mRNA in brain stem and supratentorial glioma both (R = 0.480, r = 0.809, all P <0.05). Conclusion The overexpression of N-cadherin and β-catenin play an important role in the invasion and malignant progression of human brain xenografts.