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目的:探讨硝苯地平联合倍他乐克治疗老年顽固性高血压患者的有效性和安全性。方法:2015年1月至2016年1月龙门县人民医院收治老年性顽固性高血压患者80例,随机分为观察组和对照组各40例。观察组采用硝苯地平联合倍他乐克治疗,对照组采用硝苯地平治疗。对两组患者治疗后的尿微量蛋白、尿肌酐、24 h动态血压、血清尿酸等进行检测,并统计用药过程中出现的不良反应。结果:应用硝苯地平联合倍他乐克治疗后的观察组患者的指标的改善明显优于单纯使用硝苯地平的对照组,尿微量蛋白、尿肌酐、24 h动态血压、血清尿酸等相关指标比较,差异具有统计学意义(P<0.05)。观察组不良反应发生率为10.00%,对照组为12.50%,两组不良反应的比较,差异无统计学意义(P>0.05)。两组患者均为出现严重的不良反应。结论:硝苯地平联用倍他乐克治疗老年顽固性高血压,疗效高于单一使用硝苯地平,并且有较好的安全性。
Objective: To investigate the efficacy and safety of nifedipine and metoprolol in the treatment of senile patients with refractory hypertension. Methods: From January 2015 to January 2016, 80 patients with senile refractory hypertension were admitted to Longmen People’s Hospital, and randomly divided into observation group and control group with 40 cases each. The observation group was treated with nifedipine and metoprolol, while the control group was treated with nifedipine. After treatment, the urinary microalbuminuria, urinary creatinine, 24 h ambulatory blood pressure and serum uric acid were measured in two groups of patients, and the adverse reactions in the course of treatment were counted. Results: The improvement of the index of patients in the observation group treated with nifedipine combined with metoprolol was significantly better than that of the nifedipine-only control group, urinary microalbuminuria, urinary creatinine, 24 h ambulatory blood pressure, serum uric acid and other related indicators The difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 10.00% and that in the control group was 12.50%. There was no significant difference in adverse reactions between the two groups (P> 0.05). Two groups of patients were serious adverse reactions. Conclusion: Nifedipine in combination with metoprolol in the treatment of elderly patients with refractory hypertension is more effective than nifedipine alone and has good safety.