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目的探讨联合亚标准剂量丙种球蛋白治疗特发性血小板减少性紫癜的疗效及临床分析。方法 2010年6月至2012年6月期间,我院诊治的90例特发性血小板减少性紫癜患者,随机将其分为糖皮质激素组、丙种球蛋白组、亚标准剂量丙种球蛋白组,每组各30例,对三组的出血症状控制时间、血小板上升时间、血小板恢复时间,以及三组的临床疗效,进行观察和比较。结果与糖皮质激素组相比,丙种球蛋白组和亚标准剂量丙种球蛋白组的出血症状控制时间、血小板上升时间,以及血小板恢复时间均明显缩短,总有效率明显升高,P<0.05,差异有统计学意义,与丙种球蛋白组相比,亚标准剂量丙种球蛋白组的上述指标及总有效率,均没有明显改变,P>0.05,差异无统计学意义。结论对于特发性血小板减少性紫癜的治疗,与糖皮质激素治疗相比,丙种球蛋白和亚标准剂量丙种球蛋白治疗的疗效显著,能够迅速控制出血症状,但这两种治疗的疗效比较没有明显差异。
Objective To investigate the efficacy and clinical analysis of combined sub-standard doses of gamma-globulin in the treatment of idiopathic thrombocytopenic purpura. Methods From June 2010 to June 2012, 90 patients with idiopathic thrombocytopenic purpura diagnosed and treated in our hospital were randomly divided into glucocorticoid group, gamma globulin group, sub-standard dose gamma globulin group, Each group of 30 cases, the three groups of bleeding control time, platelet rise time, platelet recovery time, and the clinical efficacy of the three groups were observed and compared. Results Compared with glucocorticoid group, the control of hemorrhagic symptoms, platelet rise time and platelet recovery time were significantly shortened and the total effective rate was significantly increased (P <0.05, P <0.05) The difference was statistically significant, compared with the gamma globulin group, sub standard dose of gamma globulin group of the above indicators and the total effective rate, no significant change, P> 0.05, the difference was not statistically significant. Conclusions The treatment of idiopathic thrombocytopenic purpura compared with glucocorticoid treatment, gamma globulin and sub-standard dose of gamma globulin treatment of significant effect, can quickly control the bleeding symptoms, but the efficacy of these two treatments is not Significant differences.