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目的观察恩替卡韦联合柔肝化纤颗粒治疗慢性乙型肝炎肝衰竭的效果。方法将80例慢性乙型肝炎肝衰竭患者随机分为治疗组40例和对照组40例。对照组予恩替卡韦片抗病毒联合常规西医治疗,治疗组在恩替卡韦片抗病毒联合常规西医治疗基础上加用柔肝化纤颗粒辨证加减。观察12周后的疗效。结果治疗组治疗12周后总有效率为78%,HBV DNA转阴率58%,对照组总有效率48%,HBV DNA转阴率48%;2组比较均有显著性差异(P均<0.05)。治疗组总胆红素、丙氨酸氨基转移酶、天门冬酸氨基转移酶、甲胎蛋白、凝血酶原时间、凝血酶原活动度、白蛋白均较对照组明显改善(P均<0.05)。治疗后2组Child-Pugh积分均减少。结论采用恩替卡韦联合柔肝化纤颗粒治疗慢性乙型肝炎肝衰竭在改善肝功能和抑制病毒复制方面均优于恩替卡韦及常规西药治疗。
Objective To observe the effect of entecavir and Rougan chemical fiber granule in treating chronic hepatitis B liver failure. Methods Eighty chronic hepatic failure patients with chronic hepatitis B were randomly divided into treatment group (40 cases) and control group (40 cases). The control group was treated with entecavir tablets combined with conventional western medicine, and the treatment group was treated with entecavir tablets combined with conventional western medicine, supplemented with Rougan chemical fiber granules. Observed 12 weeks after the curative effect. Results After treatment for 12 weeks, the total effective rate was 78%, the HBV DNA negative rate was 58%, the total effective rate was 48% and the HBV DNA negative rate was 48% in the treatment group. There were significant differences between the two groups (P < 0.05). Total bilirubin, alanine aminotransferase, aspartate aminotransferase, alpha-fetoprotein, prothrombin time, prothrombin activity and albumin in the treatment group were significantly improved compared with the control group (all P <0.05) . After treatment, Child-Pugh scores decreased in both groups. Conclusion The treatment of chronic hepatitis B with liver failure by entecavir and Rougan chemical fiber granule is superior to entecavir and conventional western medicine in improving hepatic function and inhibiting viral replication.