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为研究人眼环一磷腺苷酸(cAMP)在房水动力过程中的调节作用,应用放射免疫技术,测定了50例正常人和29例闭角型青光眼的房水cAMP含量。正常人眼房水cAMP含量为13.53±5.81pmol/ml,房水含量与年龄成正相关;急性闭角型青光眼发作期cAMP含量与眼压水平正相关,缓解期房水cAMP含量低于正常眼和发作期;慢性闭角型青光眼房水cAMP含量与眼压水平无显著相关性,但明显低于正常眼。对闭角型青光眼的发病机理也进行了讨论。
In order to investigate the regulatory effect of cyclic adenosine monophosphate (cAMP) in the aqueous humor process, radioimmunoassay was used to determine cAMP content in aqueous humor of 50 normal subjects and 29 patients with angle-closure glaucoma. Normal human aqueous humor cAMP content of 13.53 ± 5.81pmol / ml, aqueous humor content and age are positively correlated; acute angle-closure glaucoma cAMP content during intraocular pressure and intraocular pressure level is positively correlated with cAMP content in aqueous humor during remission was lower than normal eyes and seizures ; Chronic angle-closure glaucoma atrial water cAMP content and intraocular pressure did not show a significant correlation, but significantly lower than normal eyes. The pathogenesis of angle closure glaucoma is also discussed.