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本文用Ｗｉｓｔａｒ大鼠８０只，尼龙线堵塞法建立可再灌流的急性脑缺血动物模型，随机分为闭塞和再灌流两大组。根据血糖水平不同，每组又分为５个亚组。术后测定神经功能及梗塞灶体积。发现再灌流组高血糖和重度低血糖大鼠较正常血糖大鼠神经功能评分低，梗塞灶大，统计学均有显著差异。非再灌流组，只有重度低血糖大鼠较正常血糖大鼠神经功能评分低，梗塞灶大，其它各组之间神经功能评分和梗塞灶体积均无显著差异。结果表明，高血糖和重度低血糖加重脑缺血性损伤，而且血糖与局部脑缺血的影响与再灌流密切相关
In this paper, 80 Wistar rats, nylon plugging method to establish a reperfusion model of acute cerebral ischemia, were randomly divided into occlusion and reperfusion two groups. According to different blood sugar levels, each group is divided into 5 subgroups. Neurological function and infarct volume were determined after operation. Found that the reperfusion group of hyperglycemia and severe hypoglycemic rats than normal blood glucose neurological score was low, large infarction, statistics were significantly different. Non-reperfusion group, only severe hypoglycemic rats than normal blood glucose neurological score was low, infarct size, the other groups between the neurological score and infarct volume were no significant difference. The results show that hyperglycemia and severe hypoglycemia aggravate cerebral ischemic injury, and the impact of blood glucose and focal cerebral ischemia and reperfusion are closely related