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目的探讨肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)在急性胰腺炎(AP)患者中诊断及早期病情严重度评估中的价值.方法选取81例AP患者,分为轻症急性胰腺炎(MAP)组57例和重症急性胰腺炎(SAP)组24例,对SAP组和MAP组在入院后1h、24h、2d、3d、5d抽血测定TNF-α和IL-6,并对结果进行分析.结果 SAP组和MAP组在入院后1h、24h、3d检测TNF-α和IL-6的水平比较差异有统计学意义(P<0.05).结论血清TNF-α和IL-6水平变化与AP的发生发展密切相关,可作为AP病情变化和程度判断的参考指标,对AP早期严重度具有良好的预测作用.“,”Objective:To explore the value dynamic changes of serum levels of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6)and to determine their predictive value for severity and prognosis of acute pancreatitis(AP).Methods 81 patients with acute pancreatitis were divided into mild acute pancreatitis group(MAP,n=57) and severe acute pancreatitis group(SAP,n=24),SAP and MAP Group at post admission 1h,24h,3d,dedicated TNF-a and IL-6,then analysed and contrasted the results.Results The chang of TNF-a and IL-6 levels at post-admission 1h、24h、2d、3d、5d between SAP and MAP duringhospitalization in patients were statistically significant difference(P<0.05).Conclusion Dynamic changes of the serum levels of TNF-α and IL-6 are related to the occurance and development of acute pancreatitis,and the serum levels of TNF-α and IL-6 on 3rd day may be a predictive index for severity and prognosis of acute pancreatitis.