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婴儿孤独症是一严重的发育障碍,治疗效果差。过去常用氟哌啶醇治疗,据认为有减轻多动、退缩、刻板、暴怒、违拗和促进学习的作用。肌张力障碍和迟发性运动障碍是其主要副作用,为临床难以接受。近年来发现三分之一的孤独症患儿伴有5-羟色胺(5-HT)增高,而且高5-HT患儿比低5-HT患儿有更多的适应不良行为、刻板动作及更严重的认知障碍。因此,Ritvo等人推论5-HT异常是婴儿孤独症行为障碍的基础,使用相应拮抗剂或许能减轻症状。本文作者综述了近年来有关5-HT拮抗剂——氟苯丙胺(Fenfluramine)治疗孤独症的数篇文献,现摘要如下:
Infant autism is a serious developmental disorder, poor treatment. In the past, haloperidol was often used as a treatment for relief of hyperactivity, withdrawal, stereotyping, rage, misconduct, and learning promotion. Dystonia and tardive dyskinesias are their major side effects and are clinically unacceptable. In recent years, one third of children with autism have been found to have increased serotonin (5-HT), and more children with high 5-HT have more maladaptation, stereotypical behavior and more Severe cognitive impairment. Therefore, Ritvo et al. Corollary 5-HT abnormalities is the basis for autistic behavior disorders in infants, and using the appropriate antagonist may reduce the symptoms. In this review, we summarize several recent reviews of 5-HT antagonist fenfluramine in the treatment of autism. The abstract is as follows: