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目的通过搜集大肠腺瘤的患者口服大剂量阿司匹林预防大肠腺瘤复发的有效性。方法临床上行肠镜检查的发现息肉并行内镜切除病理检查为大肠腺瘤的患者150例,随机分为观察组75人和对照组75人,观察组口服阿司匹林200mg/d,对照组口服安慰剂,随访半年后行肠镜检查。结果观察组共有67例完成随访,其中共有12例复发大肠腺瘤,对照组共有73例完成随访,有25例复发大肠腺瘤。运用Stata软件对数据进行统计学分析显示相对危险度RR为0.52,可信区间CI:0.29-0.96,P=0.035<0.05,有统计学意义。结论口服大剂量阿司匹林对预防大肠腺瘤术后复发有效。
Objective To prevent the recurrence of colorectal adenoma by oral administration of large doses of aspirin in patients with colorectal adenoma. Methods 150 patients with colorectal adenoma who underwent colonoscopy by polypectomy were enrolled in this study. They were randomly divided into observation group (75 cases) and control group (75 cases). The observation group received aspirin 200 mg / d, while the control group received placebo Follow-up six months after colonoscopy. Results A total of 67 cases were followed up in the observation group, of which 12 cases were recurrent colorectal adenomas. A total of 73 cases were followed up in the control group, with 25 cases recurrent colorectal adenomas. Statistical analysis of the data using Stata software showed that the relative risk RR was 0.52, CI 0.29-0.96, P = 0.035 <0.05, with statistical significance. Conclusions Oral high-dose aspirin is effective in preventing postoperative recurrence of colorectal adenoma.