Heymann肾炎是研究人类膜性肾病的经典动物模型 ,补体攻膜复合物与Heymann肾炎的发病密切相关 ,在Heymann肾炎的发病中 ,插入肾小球上皮细胞膜的补体攻膜复合物可造成细胞的亚溶解性损伤 ,进而介导血栓素A2 、活性氧和转化生长因子 β等炎症介质的释放 ,通过不同的作用机制导致肾小球滤过屏障的损伤和蛋白尿的产生。 Heymann nephritis is a classic animal model for the study of human membranous nephropathy. The complement membrane complex is closely related to the development of Heymann nephritis. In the pathogenesis of Heymann nephritis, the complement membrane complex inserted into the glomerular epithelial cell membrane can cause subunit Lytic injury, and then mediate the release of inflammatory mediators such as thromboxane A2, reactive oxygen species and transforming growth factor β, and lead to the damage of glomerular filtration barrier and proteinuria through different mechanisms of action.