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目的：观察ＰＡＦ在内毒素血症血流动力学改变中的作用及ＰＡＦ受体拮抗剂的防治效果。方法：家兔４５只随机分成５组，观察平均动脉压（ＭＡＰ）、心率（ＨＲ）、呼吸（ＲＲ）及心功能的变化。结果：内毒素及ＰＡＦ均能引起心血管功能的显著抑制，表现为ＭＡＰ、ＬＶＳＰ、±ｄｐ／ｄｔｍａｘ明显紊乱。心血管功能紊乱与循环ＰＡＦ水平是一致的。用ＰＡＦ受体拮抗剂可显著逆转由ＰＡＦ成内毒素引起的心血管功能紊乱。结论：ＰＡＦ可能是引起内毒素血症时心功能紊乱的重要介质之一，ＰＡＦ受体拮抗剂有明显的防治作用。
Objective: To observe the role of PAF in the hemodynamic changes of endotoxemia and the preventive and therapeutic effects of PAF receptor antagonists. Methods: Forty five rabbits were randomly divided into five groups. The changes of mean arterial pressure (MAP), heart rate (HR), respiration (RR) and cardiac function were observed. Results: Both endotoxin and PAF could cause significant inhibition of cardiovascular function, with apparent disturbance of MAP, LVSP and ± dp / dtmax. Cardiovascular disorders are consistent with circulating PAF levels. PAF receptor antagonists significantly reversed cardiovascular dysfunction caused by PAF endotoxin. Conclusion: PAF may be one of the most important mediators of cardiac dysfunction caused by endotoxemia, and PAF receptor antagonists have obvious preventive and therapeutic effects.