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研究表明病毒样颗粒 (VL P)既诱导高滴度人类免疫缺陷症病毒 (HIV)特异性抗体 ,又诱导强的细胞毒性 T细胞应答。因 VLP不含包装的逆转录病毒核酸序列 ,故相当安全。作者报告了猴免疫缺陷症病毒 (SIV)Pr5 6 gag VL P对恒河猴的免疫原性及保护力。 通过将 HIV- 1 gp1 6 0衍生
Studies have shown that virus-like particles (VLPs) induce both high-titer human immunodeficiency virus (HIV) -specific antibodies and strong cytotoxic T-cell responses. It is reasonably safe because VLPs contain no packaged retroviral nucleic acid sequences. The authors report the immunogenicity and protective ability of monkey immunodeficiency virus (SIV) Pr5 6 gag VL P on rhesus monkeys. By derivatization of HIV-1 gpl60