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内皮细胞功能障碍与动脉粥样硬化、高血压、糖尿病血管并发症、胰岛素抵抗等的发生发展有密切关系。蛋白激酶C(PKC)属丝氨酸 /苏氨酸蛋白激酶家族 ,它是细胞内信号转导的重要递质 ,它的激活是内皮细胞功能紊乱的关键环节之一。PKC在细胞周期中起着调控作用 ,与各种内皮源性活性物质有着密切关系。不同的PKC亚型在各环节中具有不同的调节功能 ,研究PKC不同亚型的作用有助于进一步弄清内皮细胞功能紊乱的发病机制。
Endothelial dysfunction is closely related to the occurrence and development of atherosclerosis, hypertension, diabetic vascular complications and insulin resistance. Protein kinase C (PKC) is a family of serine / threonine protein kinases that are important transmitter of intracellular signal transduction. Its activation is one of the key links of endothelial dysfunction. PKC plays a regulatory role in the cell cycle, and has a close relationship with a variety of endothelial-derived active substances. Different PKC subtypes have different regulatory functions in all aspects. Studying the roles of different subtypes of PKC helps to further understand the pathogenesis of endothelial dysfunction.