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最近由三苯乙烯系列物合成Tamoxifen,它是(对-B-二甲氨乙氧苯基)-1,2-二苯基丁-1-烯(P-B-dime thylaminoe Thoxy-phenyl)-1,2-diphenylbut-1-ene的反异构体。人类具有抗雌激素作用,可以对无排卵的妇女诱导排卵。32例闭经和月经稀少的患者先经基础体温测定,证实无排卵或有排卵缺陷,后者是指连续测定三个月时,显示黄体期短于12天,或体温上升下降缓慢者。此后,对它们试行了Tamoxifen治疗,其中4例曾用过克罗米芬(Clomiphene)无效,有2例除克罗米芬外,还用过促性腺激素也无效。
Tamoxifen is recently synthesized from a series of tristycenes, which is PB-dimethylaminoe Thoxy-phenyl-1, 2-diphenylbut-1-ene isomers. Humans have anti-estrogen effects and can induce ovulation in anovulatory women. 32 cases of amenorrhea and menorrhagia patients confirmed by basal body temperature, no anovulation or ovulation defects, the latter refers to the continuous measurement of three months, the luteal phase shorter than 12 days, or slow rise in body temperature. Since then, they have been tried Tamoxifen treatment, of which 4 cases have been used Clomiphene (Clomiphene) is invalid, 2 cases of clomiphene in addition to the use of gonadotropin also ineffective.