论文部分内容阅读
抗药性恶性疟原虫的感染在流行区已成为人类健康的重要问题。恶性疟原虫(P.f.)除了对大剂量的氯喹具抗性外,对其他抗疟药也正逐步产生抗性。近年来的文献报道,P.f.对氯喹的抗性与药物外流增加有关,这种外流过程可被异搏定(Verapamil)和其他化合物逆转。对甲氟喹的抗性可被penfluridol逆转。P.f.的抗性机制可能类似于哺乳动物细胞的多药抗性机制,即药物外流被一种ATP依赖的外流泵所调节。本文通过一系列试验结果证实P.f至少含两种基因,其序列与哺乳动物多种药物抗性(mdr)基因相
Drug-resistant Plasmodium falciparum infection has become an important issue in human health in endemic areas. Plasmodium falciparum (P.f.) is resistant to other antimalarial drugs in addition to high doses of chloroquine. In recent years, it has been reported in literature that the resistance of P.f. to chloroquine is related to the increase of drug efflux, which can be reversed by Verapamil and other compounds. Resistance to mefloquine can be reversed by penfluridol. The resistance mechanism of P.f. may be similar to the multidrug resistance mechanism of mammalian cells, where drug efflux is regulated by an ATP-dependent efflux pump. This article through a series of test results confirmed that P.f contains at least two genes, the sequence and the mammalian multidrug resistance (mdr) gene phase