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目的探讨埃索美拉唑与苹果酸氯波比利片联合治疗糜烂性食管炎的临床疗效。方法选取通辽市医院2014年1月—2015年3月收治的糜烂性食管炎患者68例,根据不同治疗方式分为研究组和对照组,每组34例。对照组单纯采用埃索美拉唑治疗,研究组采用埃索美拉唑与苹果酸氯波比利片联合治疗,比较两组临床疗效、临床症状积分、生活质量及不良反应发生情况。结果研究组总有效率高于对照组,临床症状积分低于对照组,生活质量各评分高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论埃索美拉唑与苹果酸氯波比利片联合治疗糜烂性食管炎的临床疗效显著,不良反应少,可有效提高患者生活质量。
Objective To investigate the clinical efficacy of esomeprazole combined with clopidogrel malate in the treatment of erosive esophagitis. Methods 68 patients with erosive esophagitis treated in Tongliao Hospital from January 2014 to March 2015 were divided into study group and control group with 34 cases in each group according to different treatment methods. The control group was treated with esomeprazole alone. The study group was treated with esomeprazole and clopidogrel malate. The clinical efficacy, clinical symptom scores, quality of life and adverse reactions were compared between the two groups. Results The total effective rate in the study group was higher than that in the control group, and the clinical symptom scores were lower than those in the control group. The scores of quality of life were higher than those in the control group (P <0.05). There was no statistical difference in the incidence of adverse reactions between the two groups Significance (P> 0.05). Conclusions The combination of esomeprazole and clopidogrel malate for the treatment of erosive esophagitis has significant clinical curative effect with few adverse reactions and can effectively improve the quality of life of patients.