论文部分内容阅读
Fisher和Holfelder1930年首先描述了放射治疗引起迟发性放射性脑坏死。据统计该症的潜伏期(放射结束到出现临床症状)为3个月至19年。尽管目前对其临床表现有所认识,但诊断仍然困难,原因是①尚未确定脑组织对放射的安全阈值;②对放射耐受性个体之间的差异;③合用化疗、高血压、全身性疾病均可降低放射线损伤的阈值;④为了达到充分的治疗,加大放射剂量,超过了脑组织的耐受程度。有人强调迟发性放射性脑坏死如不予治疗,
Fisher and Holfelder first described radioactivity-induced delayed brain necrosis in 1930. According to statistics, the incubation period of the disease (end of radiation until clinical symptoms) is 3 months to 19 years. Despite the current understanding of its clinical manifestations, the diagnosis is still difficult because 1 has not yet established the safety threshold for radiation in brain tissue; 2 differences between individuals with radiation tolerance; 3 combined chemotherapy, hypertension, systemic diseases Can reduce the threshold of radiation damage; 4 In order to achieve adequate treatment, increase the radiation dose, exceeding the tolerance of the brain tissue. Some people emphasized that delayed brain necrosis, if not treated,