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目的 明确瘦素在胎盘组织中的表达定位 ,进一步探讨瘦素在妊娠期高血压疾病 (妊高征 )发病中的作用机制。方法 2 0 0 2年 6月至 2 0 0 3年 5月采用免疫组化方法检测 6 6例妊娠期高血压疾病 (分轻、中、重 3组 )及 2 5例正常对照组胎盘中瘦素的表达。结果 瘦素在各组胎盘中的定位显示差异无显著性意义 ,均弥漫性分布在滋养细胞的胞膜、胞浆及核膜 ,但中重度妊娠期高血压疾病组瘦素的表达水平显著高于对照组与轻度妊娠期高血压疾病组。结论 瘦素参与妊娠期高血压疾病的发病 ,它可以作为一种反映妊娠期高血压疾病病变的潜在临床指标 ,用来反映胎盘功能及胎盘是否缺氧。
Objective To clarify the expression and localization of leptin in placenta and to further explore the mechanism of leptin in the pathogenesis of hypertensive disorder complicating pregnancy (PIH). Methods From June 2002 to May 2003, 6 6 cases of hypertensive disorder complicating pregnancy (subgroups of light, medium and heavy) and 25 cases of normal control group were examined by immunohistochemistry Prime expression. Results The localization of leptin in placenta of each group showed no significant difference. All of them were diffusely distributed in the membrane, cytoplasm and nuclear membrane of trophoblast cells. However, the expression of leptin was significantly higher in moderate and severe hypertensive disorder group In the control group and mild gestational hypertension group. Conclusions Leptin is involved in the pathogenesis of hypertensive disorder complicating pregnancy. It can be used as a potential clinical indicator to reflect the function of placenta and hypoxia in the placenta.