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目的探讨支气管哮喘儿童血清总IgE与最大呼气中期流速变化的意义。方法选择支气管哮喘患儿23例和正常对照组16例为研究对象,采用双抗体夹心ELISA法检测血清总IgE水平,外周血嗜酸细胞计数采用全自动血液分析仪计数法。同时检测肺功能指标中的最大呼气中期流速。结果支气管哮喘患儿血清总IgE水平为(242.50±54.48)IU/ml,明显高于正常对照组(50.40±8.58)IU/ml,差异有统计学意义(P<0.01)。与正常对照组相比,哮喘组的外周血嗜酸细胞计数明显升高〔(300.00±84.05)vs(140.55±23.35)个/μl,P<0.05〕,而最大呼气中期流速显著降低〔(75.40±25.48)%vs(92.32±28.20)%,P<0.01〕。线性回归分析表明血清总IgE水平与外周血嗜酸细胞计数、体质指数、最大呼气中期流速无相关性。结论支气管哮喘患儿血清总IgE水平和外周血嗜酸细胞计数明显升高。IgE在儿童哮喘的发病机制中具有重要作用。
Objective To investigate the significance of serum total IgE and maximal expiratory flow rate in children with bronchial asthma. Methods Twenty-three patients with bronchial asthma and 16 normal controls were enrolled in this study. Serum total IgE levels were measured by double antibody sandwich ELISA. Peripheral blood eosinophils were counted by automatic hematology analyzer. Simultaneous detection of maximum expiratory flow in lung function indicators. Results The serum total IgE level in children with bronchial asthma was (242.50 ± 54.48) IU / ml, which was significantly higher than that in the normal control group (50.40 ± 8.58) IU / ml, the difference was statistically significant (P <0.01). Compared with the normal control group, the peripheral blood eosinophil counts in the asthma group were significantly higher (300.00 ± 84.05 vs 140.55 ± 23.35 / μl, P <0.05), while the maximal expiratory flow rate was significantly reduced [( 75.40 ± 25.48)% vs (92.32 ± 28.20)%, P <0.01〕. Linear regression analysis showed that there was no correlation between serum total IgE level and peripheral blood eosinophil count, body mass index and maximal expiratory flow rate. Conclusion Serum total IgE levels and peripheral blood eosinophil counts were significantly higher in children with bronchial asthma. IgE plays an important role in the pathogenesis of childhood asthma.