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目的:旨在通过问卷调查的方式探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的健康相关的生命质量（HRQOL）。方法:通过横断面研究的方式应用36项健康调查简表（SF-36）对2019年1—8月浙江医院200例OSAHS患者（OSAHS组）和50例健康人群（健康对照组）进行生命质量评价，同时进行肺活量测定以评估肺功能，应用慢性肺病（CLD）指数评估症状的严重程度，测量患者的颈围，分析各项变量与患者生命质量的相关性。结果:200例OSAHS患者病程为（2.8 ± 0.5）年，爱泼沃斯嗜睡量表（ESS）评分为（8.9 ± 0.8）分，CLD指数为（30.5 ± 2.2）分；颈围为（41.5 ± 3.8）cm。OSAHS组SF-36各项分数与健康对照组比较差异均有统计学意义（n P<0.05）。肺功能指标第1秒用力呼气容积占预计值百分比（FEVn 1%）、第1秒用力呼气容积与用力呼气容积比值（FEVn 1/FVC）与SF-36各项指标之间均存在负相关（n P<0.01）；年龄、疾病持续时间、ESS评分、颈围及体质量指数（BMI）与SF-36各项分数均存在正相关（n P<0.05）；患者的生活水平与HRQOL呈显著相关性（n χ2=71.25，n P<0.01）。n 结论:OSAHS患者的HRQOL普遍较低，肺功能不佳、病程增加、吸烟以及颈围与BMI增加、白天嗜睡加重等对HRQOL可产生不利影响。“,”Objective:To investigate the health-related quality of life (HRQOL) of patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) through a questionnaire.Methods:The study period was from January 2019 to August 2019. A cross-sectional study was used to evaluate the quality of life of all 200 subjects diagnosed with OSAHS (OSAHS group) and 50 healthy controls (healthy control group) in Zhejiang Hospital by means of 36 summary health surveys (SF-36). Spirometry was performed to assess lung function, and the chronic lung disease (CLD) severity index was used to assess the severity of symptoms, measured patients′ neck circumference, and analyzed correlations between variables and patients′ quality of life.Results:The average disease duration of the OSAHS patients was (2.8 ± 0.5) years, the average Epworth sleep scale (ESS) score was (8.9 ± 0.8) scores, the CLD index was (30.5 ± 2.2) scores, and the average neck circumference was (41.5 ± 3.8) cm, respectively. Compared with healthy control group, the OSAHS patients had significant damage in all fields, and the difference was statistically significant (n P < 0.05). Lung function indicators including the percentage of forced expiratory volume in the first second occupied estimated value (FEV n 1%), the ratio of forced expiratory volume in the first second and forced vital capacity (FEVn 1/FVC) showed negative correlations with scores of SF-36 in all fields (n P < 0.05). The age, disease duration, ESS score, neck circumference and body mass index (BMI) were associated with poor HRQOL( n P < 0.05). Patients′ living standard was significantly correlated with HRQOL ( n χ2 = 71.25, n P < 0.01).n Conclusions:The HRQOL of patients with OSAHS is generally low. Poor lung function, increased disease duration, smoking, increased neck circumference and BMI, and increased daytime sleepiness can adversely affect HRQOL.