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建立了定量核磁共振波谱法测定片剂中吡罗昔康含量的方法。以咖啡因为内标,选择~1H-NM R的脉冲程序,延迟时间为12 s,采样次数为32次,以吡罗昔康中δ2.969的峰为定量峰,咖啡因中δ4.006的峰为内标定量峰。吡罗昔康与内标咖啡因的质量比在0.25~6.0的范围内具有良好的线性关系,线性相关系数为0.9993。吡罗昔康片的加标回收率为97.7%~101.0%,相对标准偏差为0.42%~1.2%。方法可用于吡罗昔康片剂含量的测定。
A method for the determination of piroxicam in tablets by quantitative nuclear magnetic resonance spectroscopy was established. With caffeine as an internal standard, the pulse program of ~ 1H-NM R was selected with a delay time of 12 s and a sampling frequency of 32 times. The peak of δ2.969 in piroxicam was quantitatively determined. The peak of δ4.006 in caffeine was Internal standard quantitative peak. The mass ratio of piroxicam to the internal standard caffeine has a good linear relationship in the range of 0.25-6.0 with a linear correlation coefficient of 0.9993. The recoveries of piroxicam tablets ranged from 97.7% to 101.0% with relative standard deviations of 0.42% -1.2%. The method can be used to determine the content of piroxicam tablets.