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目的：探析左卡尼汀联合血液透析治疗尿毒症性周围神经病变的临床疗效。方法以80例合并尿毒症性周围神经病变的血液透析患者为研究对象，并随机分成观察组和对照组。对照组(40例)单纯进行血液透析治疗，观察组(40例)采用左卡尼汀联合血液透析进行治疗，疗程均为2个月。观察两组患者治疗前后周围神经病变的临床症状，以及正中神经、胫神经、腓总神经的感觉神经传导速度。结果经过治疗，两组患者的临床症状均得到改善，各感觉神经的传导速度也明显加快，且观察组的改善情况优于对照组，比较差异显著，P<0.05，具有统计学意义。结论左卡尼汀联合血液透析治疗尿毒症性周围神经病变能有效改善临床症状，加快感觉神经的传导速度，具有良好的临床疗效。“,”Objective To explore L-Crnitine combined hemodialysis clinical curative effect in treatment of uremic peripheral neuropathy. Methods The 80 patients with uremic peripheral neuropathy hemodialysis patients as the research object,and were randomly divided into observation group and control group.Control group (40 cases) pure hemodialysis therapy, observation group (40 cases) with L-Carnitine combined hemodialysis treatment, a course of 2 months.Observed two groups of patients before and after treatment the clinical symptoms, peripheral neuropathy, and median nerve, tibial nerve, phil total nerve sensory nerve conduction velocity. Results After treatment, two groups of patients with clinical symptoms were improved, the sensory nerve conduction velocity is significantly accelerated, and the improvement of the observation group is superior to control group, the more significant difference, P<0.05, statistically significant. Conclusion L-Carnitine combined with hemodialysis in treating uremic peripheral neuropathycan effectively improve the clinical symptoms,conduction speed of sensory nerves, has a good clinical effect.