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为探讨新生儿非感染性疾病免疫状态，本文测定了４５例新生儿非感染性疾病患儿多项免疫指标。结果显示：新生儿硬肿症患儿血 ＩＬ－２水平、ＮＫ细胞活性明显低于对照组及其它患儿（Ｐ＜０．０１），ＳＩＬ－２Ｒ水平及Ｔ_ｓ抑制率则明显增高（Ｐ＜０．０１），所有患儿血清Ｉｇ水平均无明显变化（Ｐ＞０．０５）。ＩＬ－２水平与ＮＫ细胞活性及Ｔ_ｓ抑制率与 ＳＩＬ－２Ｒ水平间均呈正相关（ Ｐ ＜０． ０１），ＩＬ－２水平与 ＳＩＬ－２Ｒ水平、Ｔ_ｓ抑制率与 ＩＬ－２水平及 ＮＫ细胞活性、ＳＩＬ－２Ｒ水平与 ＮＫ细胞活性间均呈负相关（ Ｐ＜０．０１）。提示，新生儿硬肿症患儿细胞免疫功能降低，此可能是其易并发感染的原因之一。
In order to explore the immune status of neonatal noninfectious diseases, we measured a number of immunosuppressive markers in 45 neonates with noninfectious diseases. The results showed that the levels of IL-2 and NK cells in children with scleredema were significantly lower than those in control group and other children (P <0.01), and the levels of SIL-2R and T_s were significantly increased (P < 0.01), all children had no significant changes in serum Ig levels (P> 0.05). There was a positive correlation between IL-2 level, NK cell activity and T_s inhibition rate and SIL-2R level (P <0.01), IL-2 level and SIL-2R level, T_s inhibition rate and IL-2 level and NK cell There was a negative correlation between activity and SIL-2R level and NK cell activity (P <0.01). Tip, neonatal scleredemia in children with decreased cellular immunity, which may be one of the reasons for its easy to complicated infection.