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目的 :探讨细胞凋亡与心脏移植急、慢性排斥反应之间的关系。方法 :Wistar大鼠为供体 ,SD大鼠为受体 ,心脏移植术后给予环孢霉素A(CsA)治疗 ,在移植术后的不同时间 ,取下移植心脏 ,流式细胞术测定移植心脏组织的细胞凋亡率。结果 :CsA治疗的慢性排斥反应组 ,移植心脏的细胞凋亡率显著增高。结论 :细胞凋亡参与移植排斥反应 ,移植心脏细胞凋亡率的检测可作为诊断排斥反应和移植物能否长期存活的指标之一。
Objective: To investigate the relationship between apoptosis and acute and chronic rejection of heart transplantation. Methods: Wistar rats were used as donors and SD rats as recipients. CsA was given after heart transplantation. Hearts were removed at different time points after transplantation. Flow cytometry Cardiac tissue apoptosis rate. Results: In the chronic rejection group treated with CsA, the apoptotic rate of transplanted heart was significantly increased. CONCLUSION: Apoptosis is involved in allograft rejection and the detection of apoptotic rate in cardiac allografts can be used as an indicator of long-term graft rejection and rejection.