论文部分内容阅读
母乳性黄疸(BJ)是由母乳喂养引起的黄疸,随着居民生活水平提高,国内外该症发生率增高已引起临床重视。现将本院两年所接诊的11例报告如下。1 临床资料 男6例,女5例,均为足月儿。年龄分别为15～30天3例,20天～1月6例,1月～2月2例。11例患儿除黄疸外,生长发育正常,精神食欲好,体查未发现阳性体征。实验室资料:所有病例肝功能正常;凡登白试验间接反应阳性;黄疸指数35～110U;血清碱性磷酸酶小于12金氏单位;血常规正常,尿三胆阴性,无血红蛋白尿,粪胆元阳性。接诊后均未予特殊治疗,确诊后出院,3月后随访黄疸均自然消退,无一例出现核黄疸等后遗症。2 讨论 发生机理至今仍有争论,60年代起学说众多,目前偏于二种学说。一种认为是母乳中脂肪酶活性增高致乳中游离脂肪酸含量增高,抑制肝内葡糖醛酸酶,使胆红素与葡糖醛酸结合受阻,血中非结合胆红素增高。另一种认为母乳中β-葡糖醛酸酶是母乳
Breast milk jaundice (BJ) is caused by breastfeeding jaundice, as residents living standards improve, the incidence of this disease at home and abroad has caused clinical attention. Now the hospital received two cases of two cases are as follows. A clinical data of 6 males and 5 females, all term infants. The patients were aged 15 to 30 days in 3 cases, 20 days to January in 6 cases, and January to February in 2 cases. 11 cases of children except jaundice, growth and development of normal, good appetite, physical examination found no positive signs. Laboratory data: all cases of normal liver function; Vandenbai test indirectly positive; jaundice index 35 ~ 110U; serum alkaline phosphatase less than 12 units of gold; normal blood, urinary tricolor negative, hemoglobinuria, fecal Yuan positive. No specific treatment after the admissions, diagnosed after discharge, follow-up after jaundice in March were spontaneous regression, no case of complications such as nuclear jaundice. 2 Discussion Mechanism There is still controversy, since the 1960s many theories, the current partial to two theories. One is that the increase in lipase activity in breast milk increased the content of free fatty acids in the milk, inhibiting liver glucuronidase, bilirubin and glucuronic acid binding blocked, increased blood unconjugated bilirubin. Another is that beta-glucuronidase in breast milk is breast milk