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目的:探讨nm23H1和PTEN基因蛋白在胆囊癌中表达的意义。方法:应用免疫组化方法,检测52例胆囊腺癌、20例胆囊腺瘤和10例慢性胆囊炎组织中nm23H1和PTEN表达水平。结果:在胆囊癌中nm23H1和PTEN表达阳性率分别为51.9％和42.3％,其表达阳性率均明显低于胆囊腺瘤和慢性胆囊炎(P<0.05)。nm23H1和PTEN表达与胆囊癌的分化程度、浆膜浸润和转移密切相关(P<0.05)。nm23H1和PTEN蛋白表达呈正相关(r=0.56,P<0.05)。结论:检测nm23H1和PTEN基因蛋白表达可作为评价胆囊癌生物学行为的参考指标。
Objective: To investigate the expression of nm23H1 and PTEN in gallbladder carcinoma. Methods: The expressions of nm23H1 and PTEN in 52 cases of gallbladder adenocarcinoma, 20 cases of gallbladder adenoma and 10 cases of chronic cholecystitis were detected by immunohistochemistry. Results: The positive rates of nm23H1 and PTEN in gallbladder carcinoma were 51.9% and 42.3%, respectively, which were significantly lower than those of gallbladder adenoma and chronic cholecystitis (P <0.05). The expression of nm23H1 and PTEN was closely related to the differentiation of gallbladder carcinoma, serosa invasion and metastasis (P <0.05). There was a positive correlation between nm23H1 and PTEN protein expression (r = 0.56, P <0.05). Conclusion: The detection of nm23H1 and PTEN gene protein expression can be used as a reference to evaluate the biological behavior of gallbladder cancer.