从Ellouz等(1974年)首次报道细菌细胞壁最小结构亚单位胞壁酰二肽(MOP)具有佐剂活性以来,现已报告了MDP及其衍生物的各种生物学活性。在实验肿瘤系统中,单独MDP在体内不显示抗肿瘤活性,而将MDP的类似物与海藻糖二霉菌酸酯(TDM)配制成水油乳剂,注入同种同基因品系2的 A variety of biological activities of MDP and its derivatives have been reported since Ellouz et al. (1974) first reported the adjuvant activity of muramyl dipeptide (MOP), the smallest structural subunit of the bacterial cell wall. In the experimental oncology system, MDP alone did not show antitumor activity in vivo, whereas analogs of MDP and trehalose dimylate (TDM) were formulated as a water-oil emulsion and injected into the same syngeneic line 2