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目的：探讨神经内分泌肿瘤诊断中神经元特异性烯醇化酶（ＮＳＥ），嗜铬素Ａ（ＣｇＡ），突触素（Ｓｙｎ）的应用价值。方法：应用免疫组化ＬＳＡＢ法对９９例不同部位及激素活性的神经内分泌肿瘤进行ＮＳＥ，ＣｇＡ，Ｓｙｎ标记。结果：３种标记物在神经内分泌肿瘤中的阳性率分别为ＮＳＥ９４．９％，ＣｇＡ７０．７％，Ｓｙｎ７５．８％。３种标记物共同表达率为５８．６％，高于单项（１５．２％）和双项（２５．３％）标记物表达率，有９８例标本至少显示１种标记物阳性。结论：３种标记物的表达与肿瘤部位和激素活性无关，三者联合应用可提高神经内分泌肿瘤的诊断率
Objective: To investigate the value of neuron-specific enolase (NSE), chromogranin A (CgA) and synaptophysin (Syn) in the diagnosis of neuroendocrine tumors. METHODS: NSE, CgA and Syn markers were performed on 99 neuroendocrine tumors with different sites and hormonal activity using immunohistochemical LSAB method. Results: The positive rates of the three markers in neuroendocrine tumors were NSE 94.9%, CgA 70.7%, and Syn 75.8%, respectively. The co-expression rate of the three markers was 58.6%, which was higher than that of the single (15.2%) and double (25.3%) markers. In 98 specimens, at least one marker was positive. Conclusion: The expression of these three markers is not related to tumor site and hormonal activity. The combination of these three markers can improve the diagnostic rate of neuroendocrine tumors.