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整合素是一类重要的黏附分子,主要介导细胞与细胞外基质(ECM)及细胞与细胞间黏附,以及细胞内、外的信息传递,并影响血管生成。整合素通过调节细胞的生长、分化、增殖,在肿瘤的生成、侵袭、转移以及肿瘤血管的生成过程中起着重要作用。整合素β1是整合素家族中最大的亚群,通过多条通路介导细胞黏附、信号传导等,对肿瘤的生成及转移有着重要的影响。本文着重对整合素β1的结构、生物学功能,以及它与头颈部肿瘤的关系、相关的肿瘤治疗做一综述。
Integrins are an important class of adhesion molecules that mainly mediate cellular and extracellular matrix (ECM) and cell-cell adhesion as well as intracellular and extracellular information transmission and affect angiogenesis. Integrins play an important role in tumorigenesis, invasion, metastasis and tumor angiogenesis by regulating cell growth, differentiation and proliferation. Integrin β1 is the largest subfamily of integrins and plays an important role in tumorigenesis and metastasis through multiple pathways that mediate cell adhesion and signal transduction. This article focuses on the structure of integrin β1, biological function, as well as its relationship with head and neck cancer, related to the treatment of cancer are reviewed.