严重的难治性溃疡性结肠炎病因未明,据信与免疫机制有关,以往主要用静脉注射大剂量皮质激素治疗,治疗5～10天无效者需行结肠切除术。本文作者试用环孢菌素对一组经皮质激素治疗无效的严重溃疡性结肠炎患者进行治疗。本组15例患者中男11例,女4例,平均年龄30.6(12～52)岁,平均病程3.8年(8个月～12年),均经临床、内窥镜和/或放射检查确诊。其中12例病 The cause of severe refractory ulcerative colitis is unknown. It is believed that it is related to the immune mechanism. In the past, intravenous high-dose corticosteroids were mainly used in the treatment of those who were ineffective for 5 to 10 days. The authors tested cyclosporin in a series of patients with severe ulcerative colitis who did not respond to corticosteroid therapy. This group of 15 patients, 11 males and 4 females, mean age 30.6 (12 to 52) years, the average duration of 3.8 years (8 months to 12 years), were clinically confirmed by endoscopy and / or radiological examination . Twelve of them were ill