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目的:分析非小细胞肺癌(NSCLC)组织中DNA修复基因Xeroderma Pigmentosum Group A(XPA)的表达状况及其与临床病理特征的关系。方法:采用免疫组织化学方法(IHC)检测初治中晚期NSCLC患者癌组织中XPA的表达状况,采用χ2检验比较各亚组之间的XPA表达状况的差异。结果:109例NSCLC组织中XPA的阳性表达率为55.0%(60/109),其表达与性别、吸烟史有密切关系,在男性组中的阳性率(61.0%)显著高于女性组(37.0%)(P=0.030);吸烟组的XPA阳性率显著高于不吸烟组(分别为68.1%和45.2%,P=0.017);但在吸烟人群中,吸烟量不同的亚组间XPA的表达率未见明显差异。XPA阳性率在不同年龄、临床TNM分期、组织学类型或分化程度、淋巴结转移和远处转移亚组中的差异均无统计学意义(均P>0.05)。结论:XPA在NSCLC组织中的表达状况与性别、吸烟状况密切相关,并可能与NSCLC的发生有关。
Objective: To analyze the expression of DNA repair gene Xeroderma Pigmentosum Group A (XPA) in non-small cell lung cancer (NSCLC) and its relationship with clinicopathological features. METHODS: Immunohistochemistry (IHC) was used to detect the expression of XPA in cancer tissues from patients with advanced NSCLC. The χ2 test was used to compare the differences in XPA expression among the subgroups. Results: The positive expression rate of XPA in 109 NSCLC tissues was 55.0% (60/109). The expression of XPA was closely related to sex and smoking history. The positive rate in male group (61.0%) was significantly higher than that in female group (37.0). %) (P=0.030); The XPA positive rate in the smoking group was significantly higher than that in the non-smoking group (68.1% and 45.2%, respectively, P=0.017); but in the smoking population, the XPA expression was different among the smoking groups. No significant difference in rates. There was no significant difference in XPA positive rate among different ages, clinical TNM stage, histological type or differentiation degree, lymph node metastasis and distant metastasis subgroup (all P>0.05). Conclusion: The expression of XPA in NSCLC tissues is closely related to gender and smoking status, and may be related to the occurrence of NSCLC.