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目的:分析雷贝拉唑和克拉霉素联合阿莫西林疗法治疗胃溃疡的临床效果,为临床工作者提供参考。方法:回顾分析自2013年12月-2014年10月巫山县中医院收治的128例胃溃疡患者的临床资料。随机将其均分为观察组和对照组。给予观察组(n=64)雷贝拉唑和克拉霉素联合阿莫西林治疗,疗程为2周;给予对照组(n=64)奥美拉唑和克拉霉素联合阿莫西林,疗程2周。观察分析两组的治疗效果和不良反应情况。结果:经过2周治疗,观察组治疗显效28例,治疗有效34例,治疗无效2例,治疗有效率为96.88%;对照组治疗显效21例,治疗有效34例,治疗无效9例,治疗有效率为85.94%。组间比较,差异有统计学意义(P<0.05)。患者的血清白细胞介素2(IL-2)水平增多、白细胞介素6(IL-6)和C-反应蛋白(CRP)减少,治疗前后差异有统计学意义(P<0.05)。IL-2、IL-6和CRP在组间比较,差异有统计学意义(P<0.05)。恶心、腹泻、皮疹和头昏等不良反应,观察组出现7例,对照组出现16例,不良反应发生率在组间比较,差异有统计学意义(P<0.05)。结论:雷贝拉唑和克拉霉素联合阿莫西林疗法治疗胃溃疡的临床效果佳,不良反应少,具有应用价值。
Objective: To analyze the clinical effects of rabeprazole and clarithromycin combined with amoxicillin in the treatment of gastric ulcer, and provide a reference for clinicians. Methods: The clinical data of 128 patients with gastric ulcer admitted to Wushan Hospital of Traditional Chinese Medicine from December 2013 to October 2014 were retrospectively analyzed. Randomly divided into observation group and control group. Patients in the observation group (n = 64) were treated with rabeprazole and clarithromycin in combination with amoxicillin for 2 weeks. Omeprazole and clarithromycin plus amoxicillin were given to the control group (n = 64) week. Observation and analysis of the two groups of treatment and adverse reactions. Results: After 2 weeks of treatment, the observation group was significantly improved in 28 cases, effective in 34 cases, ineffective in 2 cases, effective rate was 96.88%; control group, 21 cases were effective, effective treatment in 34 cases, ineffective in 9 cases, treatment of Efficiency is 85.94%. The differences between the two groups were statistically significant (P <0.05). The level of serum interleukin 2 (IL-2), interleukin 6 (IL-6) and C-reactive protein (CRP) were decreased in patients before and after treatment (P <0.05). The difference of IL-2, IL-6 and CRP between the two groups was statistically significant (P <0.05). Nausea, diarrhea, rashes and dizziness and other adverse reactions, the observation group appeared in 7 cases, the control group appeared in 16 cases, the incidence of adverse reactions in the comparison between groups, the difference was statistically significant (P <0.05). Conclusion: Rabeprazole and clarithromycin combined with amoxicillin in the treatment of gastric ulcer with good clinical effect, fewer adverse reactions, with application value.