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Purpose:To investigate the effectiveness of needle revision combined with subconjuctival injection of interferon α-2b in reversing early scarring of filtering blebs following trabeculectomy surgery.Methods:Twenty-five glaucoma patients (31 eyes) who presented with scarred or encapsulated filtering bleb after glaucoma surgery underwent needle revision in combination with subconjuctival injection of interferon α-2b,and were followed for 12 months.Intraocular pressure (IOP) and filtering bleb morphology were observed post treatment.Results:The mean time until scarring occurred was 21.0±7.4 days.The average time between recognition of bleb scarfing and completion of needle revision was 2.2±0.8 days.The time interval between surgery and needle revision was inversely correlated with the time until needle revision (r =-0.694,P ＜0.001).The mean IOPs before and after needle revision were 24.2±2.7 mmHg and 19.6±3.8 mmHg,respectively (t =5.916,P ＜ 0.001).At the 12-month follow-up visit,18 eyes (58.1％) achieved complete success in IOP control,and 6 eyes (19.4％) had conditional success.The overall success rate for needling was thus 77.4％.Subconjunctival hemorrhage was observed in 4 eyes during the needle revision procedure.Punctate staining was found in the ceal epithelium of 2 eyes.Shallow anterior chamber (Grade Ⅰ or Ⅱ) was identified in 5eyes.Conclusion:Slit-lamp needle revision combined with subconjunctival injection of interferon α-2b may be efficacious in the treatment of early scarring of filtering blebs,easy and safe to perform,and may be considered for more widespread application.(Eye Science 2011 ; 26:197-200 )