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目的:了解妊娠期甲状腺功能减退症发病率对妊娠结局影响,探讨新型干预模式。方法:深圳市宝安区妇幼保健院产前门诊自2008年1月1日~2009年12月30日对2 928例孕前有高危因素及孕期系统保健的妇女进行甲状腺功能筛查:利用化学发光法检测血清FT3、FT4、TSH。结果:正常2 525例,占86.23%;异常403例,占13.76%,其中低T4血症127例,占4.43%,TSH升高(亚临床甲减者)139例,占4.75%,甲减103例,占3.51%,甲亢34例,占1.16%。针对筛查监测结果,建立早期干预新模式及效果评价,干预后甲减5例,占1.24%,亚临床甲减30例,占7.45%,低T4血症7例,占1.74%。结论:干预组亚临床甲减病症、低T4血症发生率低,早期干预可以减少并发症及出生缺陷的发生。
Objective: To understand the influence of the incidence of hypothyroidism during pregnancy on the outcome of pregnancy and explore a new intervention model. Methods: Prenatal clinic of Bao’an District Maternal and Child Health Hospital of Shenzhen City was conducted from January 1, 2008 to December 30, 2009 on 2928 women with high risk factors and systemic health care during pregnancy. Thyroid function screening was performed by chemiluminescence Serum FT3, FT4, TSH were detected. Results: 2 525 cases were normal, accounting for 86.23%; 403 cases were abnormal, accounting for 13.76%, of which 127 cases were hypokalemia (4.43%), 139 cases were TSH (subclinical hypothyroidism), accounting for 4.75% 103 cases, accounting for 3.51%, 34 cases of hyperthyroidism, accounting for 1.16%. According to the results of screening and monitoring, a new mode of early intervention and evaluation of effect were established. After hypothyroidism, 5 cases were hypothyroidism, accounting for 1.24%, subclinical hypothyroidism was 30 cases, accounting for 7.45%, and 7 cases were hypokalemia, accounting for 1.74%. Conclusion: The incidence of hypothyroidism and hypothyroidism in intervention group is low. Early intervention can reduce the incidence of complications and birth defects.