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目的：比较卡马西平与阿普唑仑治疗酒精戒断反应的疗效。方法：男性酒精依赖病人的戒断症状３３例，其中１６例（年龄４５±ｓ１０ａ）采用阿普唑仑１．２－４．８ｍｇ／ｄ，ｐｏ，共２ｗｋ。另１７例（年龄４６±１０ａ）采用卡马西平３００－９００ｍｇ／ｄ，ｐｏ，共２ｗｋ作对照，结果：卡马西平对酒精戒断症状有效。２组病人在治愈率、戒断症状量表及ＨＡＭＡ量表减分率方面均有显著疗效（Ｐ＜０．０１），但组间比较无显著性差异。结论：因卡马西平无成瘾性，故适用于门诊及院外酒精戒断反应的治疗。
OBJECTIVE: To compare the efficacy of carbamazepine and alprazolam in the treatment of alcohol withdrawal. Methods: There were 33 abstinence symptoms in male patients with alcohol dependence, of which 16 (age 45 ± s10a) were treated with Alprazolam 1.2-4.8 mg / d, po for 2 weeks. Another 17 patients (age 46 ± 10a) were treated with carbamazepine 300-900mg / d, po for 2wk. Results: Carbamazepine was effective in treating alcohol withdrawal symptoms. The two groups of patients in the cure rate, withdrawal symptoms scale and HAMA scale reduction rates were significant (P <0.01), but no significant difference between groups. Conclusion: Because of no addiction of carbamazepine, it is suitable for the treatment of outpatient and out-of-hospital alcohol withdrawal response.