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类风湿关节炎(RA)是在环境因素、遗传背景以及两者交互作用下,高度异质性的自身免疫性疾病. 由于自身免疫耐受被打破,导致免疫细胞和炎性因子活化,自身抗体生成,最终因炎症瀑布放大和慢性炎症造成骨质破坏和关节重构. 近年来,研究发现神经免疫调节网络在 RA 的发病中具有重要作用,是对其发病机制的重要补充.“,”Rheumatoid arthritis is a kind of autoimmune diseases with high heterogeneity , etiology of rheumatoid arthritis is attributed to the environmental factors,gene as well as environmental-genetic interac-tion.Due to the loss of immune tolerance,activated immune cells produce specific autoantibodies and syner-gize with pro-inflammatory cytokines.The amplified inflammation cascade and chronical inflammation lead to the joint destruction and remodeling.In recent years,studies have found that the neuro-immune modulating network plays an important role in the incidence of rheumatoid arthritis and can be a complement of the path-ogenesis of rheumatoid arthritis.