目的　探讨内皮素 (ET)在急性脑卒中发生、发展中的作用。方法　采用放射免疫分析法检测12 0例急性脑卒中患者 14天内血浆 ET水平变化。结果　 (1)急性脑卒中患者血浆 ET水平 (114.75± 15 .78)明显高于对照组 (6 6 .75± 7.2 3) (P<0 .0 0 1) ;(2 )血浆 ET水平与病情轻重密切相关 ,重型 (140 .5 7± 13.84)明显高于轻型 (92 .30± 4.2 6 ) (P<0 .0 0 1) ;(3)血浆 ET水平 14天内的动态变化 :其高峰值与卒中后脑水肿、低灌流、缺血区半暗带及蛛网膜下腔出血后脑血管痉挛的形成时程相一致。结论　急性脑卒中的病理生理机理与 ET分泌异常有关 ,监测血浆 ET水平有助于判断预后 Objective To investigate the role of endothelin (ET) in the occurrence and development of acute stroke. Methods Radioimmunoassay was used to detect the changes of plasma ET level in 14 days in 120 stroke patients. Results (1) The plasma ET level in patients with acute stroke (114.75 ± 15.78) was significantly higher than that in the control group (66.75 ± 7.23) (P0.01); (2) (140.57 ± 13.84) were significantly higher than those of mild type (92.3 ± 4.2 6) (P <0.01). (3) The dynamic change of plasma ET level within 14 days: the peak value It is consistent with the formation of cerebral vasospasm after cerebral edema, hypoperfusion, ischemic penumbra and subarachnoid hemorrhage. Conclusions The pathophysiological mechanism of acute stroke is related to abnormal ET secretion. Monitoring plasma ET level may be helpful in judging the prognosis