This study aims to investigate the effect of different local testicular treatments and validate common prognostic factors on primary testicular lymphoma (PTL) patients.We retrospectively reviewed the clinical records of 32 patients from 1993 to 2017 diagnosed with PTL and included 22 patients for analysis.The Kaplan-Meier method,Log-rank test,and multivariate Cox proportional hazard regression analysis were applied to evaluate progression-free survival (PFS),overall survival (OS),and determine prognosis predictors.The median follow-up time was 30 months.Median OS and PFS were 96 months and 49 months,respectively.In univariate analysis,advanced Ann Arbor stage (Ⅲ/Ⅳ) (P ＜ 0.001),B symptoms (P ＜ 0.001),and extranodal involvement other than testis (P =0.001) were significantly associated with shorter OS and PFS.In multivariate analysis,Ann Arbor stage was significantly associated with OS (OR =11.58,P =0.049),whereas B symptom was significantly associated with PFS (OR =11.79,P =0.049).In the 10 patients with the systemic usage of rituximab,bilateral intervention could improve median OS from 16 to 96 months (P =0.032).The study provides preliminary evidence on bilateral intervention in testes in the rituximab era and validates common prognostic factors for Chinese PTL patients.