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肝细胞膜上存在特异性半乳糖受体，能专一识别末端为半乳糖基的糖蛋白配体并主动转运入细胞内。我们选用乳糖化人血清白蛋白（Ｌ－ＨＳＡ）为导向载体，与抗病毒药物单磷酸阿糖腺苷（Ａｒａ－ＡＭＰ）交联，形成乳糖化人血清白蛋白单磷酸阿腺苷（Ｌ－ＬＳＡ－Ａｒａ－ＡＭ...
There is a specific galactose receptor on the liver cell membrane, which can specifically recognize the glycoprotein ligand with galactosyl end and actively transport into the cell. We used L-HSA as a targeting vector to cross-link with the antiviral drug Ara-AMP to form the lactalbumin-human serum albumin-adenosine monophosphate (L- LSA-Ara-AM ...