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[目的]探讨乳腺印戒细胞癌的临床病理特征。[方法]收集确诊的6例乳腺印戒细胞癌患者的临床、光镜、免疫组化资料。[结果]患者主要症状为局部肿块,镜下表现为与小叶癌相关和导管癌相关。印戒细胞胞质内黏液AB染色呈蓝色,黏液卡红染色呈红色。免疫组化CK7、GCDFP-15、MG、ER、PR均阳性,CK20为阴性,患者血清中乳酸脱氢酶未见明显升高,而白细胞介素6和白细胞介素12的含量明显高于正常值。[结论]乳腺印戒细胞癌临床注意与分泌性癌、转移性印戒细胞癌和富于糖原的透明细胞癌进行鉴别。
[Objective] To investigate the clinicopathological features of breast signet-ring cell carcinoma. [Methods] Clinical, light microscopic and immunohistochemical data of 6 patients with confirmed signet-ring cell carcinoma of the breast were collected. [Results] The main symptoms of the patients were local masses, which were related to lobular carcinoma and ductal carcinoma. Signet ring cell cytoplasm AB staining was blue, mucus card red staining was red. Immunohistochemical staining for CK7, GCDFP-15, MG, ER, and PR were positive, CK20 was negative, no significant increase in serum lactate dehydrogenase, and interleukin-6 and interleukin-12 levels were significantly higher than normal value. [Conclusion] Clinical signification of breast signet-ring cell carcinoma was differentiated from secretory cancer, metastatic signet-ring cell carcinoma and glycogen-rich clear cell carcinoma.