为探讨一氧化氮在新生儿缺氧缺血性脑病 (HIE)中的作用 ,对 2 6例新生儿 HIE血浆 NO水平进行检测 ,并与 2 8例正常新生儿对照组比较 ,发现 2 6例新生儿 HIE组 NO水平显著增高 ;HIE重度者血浆 NO水平与轻、中度患儿比较 ,亦显著升高 ,说明NO在新生儿 HIE的发病过程中具有重要意义 ,检测血浆 NO,可用于估计 HIE脑损伤的严重程度 ,并可为其治疗及改善预后提供新的理论依据 In order to explore the role of nitric oxide in neonatal hypoxic-ischemic encephalopathy (HIE), NO levels in 26 HIE neonates were measured and compared with 28 normal neonatal control subjects, 26 Neonatal HIE group NO levels were significantly higher; HIE severe plasma NO levels compared with mild to moderate children also significantly increased, indicating NO in the pathogenesis of neonatal HIE is of great significance, the detection of plasma NO, can be used to estimate HIE brain injury severity, and provide a new theoretical basis for its treatment and prognosis