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目的对应用胃三联或胃四联治疗消化性溃疡(PU)的疗效进行分析。方法对480例幽门螺杆菌(HP)感染阳性的PU患者,应用胃三联(奥美拉唑、克拉霉素、替硝唑)或胃四联(甲氰咪胍、甲硝唑、阿莫西林、维生素B6),采取随机分组治疗,并对疗效对比分析。结果两组总有效率分别为95.9%和88.1%,两者之间差异无统计学意义(P>0.05),HP根除率90%以上;症状缓解时间分别平均为2.5d和5.5d。结论HP感染可能是引起PU最重要的致病因素,且和胃癌的发生密切相关。
Objective To analyze the curative effect of treating peptic ulcer (PU) with triple therapy of stomach or stomach. Methods A total of 480 cases of PU patients with positive Helicobacter pylori (HP) infection were treated with triple therapy combined with omeprazole, clarithromycin, tinidazole or metronidazole (mecamidine, metronidazole, amoxicillin , Vitamin B6), to take a randomized treatment, and comparative analysis of the curative effect. Results The total effective rates of the two groups were 95.9% and 88.1%, respectively. There was no significant difference between the two groups (P> 0.05). The eradication rate of HP was over 90%. The average symptom relief time was 2.5d and 5.5d respectively. Conclusion HP infection may be the most important causative agent for PU and is closely related to the occurrence of gastric cancer.