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目的探究手术联合术后放疗治疗宫颈癌IB期与IIA期患者的临床疗效与安全性。方法选取新疆维吾尔自治区人民医院自2011年3月至2012年3月收治的120例IB期与ⅡA期宫颈癌患者作为研究对象,采取随机数字表法分为观察组和对照组,每组各60例,观察组患者采取手术切除联合术后放疗的治疗方式,对照组患者则只采取手术切除的治疗方式。对比分析两组患者治疗后并发症的发生情况以及治疗后患者肿瘤的复发情况。结果观察组并发症的发生率为11.67%,对照组并发症的发生率为33.33%,组间比较具有显著性差异(x~2=4.97,P<0.05)。观察组在治疗后1年、2年、3年的复发率分别为0、3.33%、5.00%,对照组在治疗后1年、2年、3年的复发率分别为11.67%、21.67%、35.00%,组间相比具有显著差异(x~2值分别为4.85、5.12、5.17,均P<0.05)。结论手术联合术后放疗治疗宫颈癌IB期与IIA期患者可以明显降低患者的死亡率并增强患者对不良反应的耐受性,提高患者的生存质量,具有积极的临床价值,可以作为一种安全有效的方法应用于临床工作中。
Objective To investigate the clinical efficacy and safety of surgery combined with postoperative radiotherapy for patients with stage IB and stage IIA cervical cancer. Methods A total of 120 patients with stage IB and stage IIA cervical cancer admitted to the People’s Hospital of Xinjiang Uygur Autonomous Region from March 2011 to March 2012 were selected as study subjects and randomly divided into observation group and control group with 60 Cases, the observation group patients with surgical resection combined with postoperative radiotherapy treatment, the control group of patients only take surgical resection of the treatment. Comparative analysis of two groups of patients after treatment, the incidence of complications and tumor recurrence after treatment. Results The complication rate in the observation group was 11.67%. The incidence of complications in the control group was 33.33%. There was significant difference between the two groups (x ~ 2 = 4.97, P <0.05). The recurrence rates of the observation group at 1 year, 2 years and 3 years after treatment were 0, 3.33% and 5.00% respectively. The recurrence rates of the control group at 1 year, 2 years and 3 years after treatment were 11.67% and 21.67% 35.00%, there were significant differences between groups (x ~ 2 values were 4.85,5.12,5.17, all P <0.05). Conclusions Surgery combined with postoperative radiotherapy for patients with stage IB and stage IIA cervical cancer can significantly reduce the mortality of patients and enhance patient tolerance to adverse reactions and improve the quality of life of patients with positive clinical value and can be used as a safe Effective method used in clinical work.